Baseline endogenous glucose production prior to a mixed meal tolerance test (placebo) and following 6 weeks of either sitagliptin, metformin or sitagliptin plus metformin combination therapy in all 16 participants Average of Plasma Glucose During Mixed Meal Tolerance Test (MTT) Compared to Baseline Plasma Glucose to Post Therapy (6-weeks). Laura A. Schalliol PharmD, BCACP, Sidhartha D. Ray PhD, FACN, in Side Effects of Drugs Annual, 2019. All these findings elucidate that EPCs dysfunction could be an alternative therapeutic target to promoting heart and vessels repair in patients with DM. 2013 May 7;2(1):67-71. doi: 10.3109/21556660.2013.801605. Therefore, the Agencys view was that, as for Janumet, the benefits of Sitagliptin/Metformin hydrochloride Accord outweigh the identified risks and it can be authorised for use in the EU. There is evidence regarding potent possibilities to improve the EPCs capacity using various methods, i.e. Metformin and sitagliptin may also Fixed Dose Combination of Sitagliptin and Metformin Metformin and sitagliptin have independent glucose lowering properties and may increase GLP-1 levels by working through complementary mechanisms. Thus, the EPCs may enhance the balance between heart and vascular injury and repair that is critical for the maintenance of cardiac remodeling, heart function, intimal integrity, endothelial function, and prevention of CV complications [96]. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. This site complies with the HONcode standard for trustworthy health information: verify here. DPP-4 inhibitors inhibit glucagon secretion. Half-life of saxagliptin is 12.4h (Merck and Co, 2010). Ann Emerg Med. This medicine is authorised for use in the European Union. Last updated on May 30, 2022. Cmax is reported for sitagliptin 50 mg, metformin 500 mg and metformin 850 mg. Keywords provided by Merck Sharp & Dohme LLC: Drug: Co-administration of 50 mg sitagliptin and 500 mg metformin, Drug: sitagliptin/metformin 50 mg/500 mg tablet, Drug: Co-administration of 50 mg sitagliptin and 850 mg metformin, Drug: sitagliptin/metformin 50 mg/850 mg tablet. Find information on medicines by active ingredient or brand name. Metformin works mainly by inhibiting glucose production and reducing its absorption in the gut. For this medicine, the following should be considered: Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. G. Bebernitz, in Comprehensive Medicinal Chemistry III, 2017. HHS Vulnerability Disclosure, Help 1998-2023 Mayo Foundation for Medical Education and Research (MFMER). Intestine-liver crosstalk in Type 2 Diabetes and non-alcoholic fatty liver disease, Best Practice & Research Clinical Endocrinology & Metabolism, Endothelial progenitor cells dysfunction and impaired tissue reparation: The missed link in diabetes mellitus development, Diabetes & Metabolic Syndrome: Clinical Research & Reviews. Methods: This double-blind study (18-week Phase A and 26-week Phase B) randomized 1250 drug Radiologic procedures (eg, X-rays, CT scans, and MRIs) that require dyes to be injected into your veinThis medicine should be stopped before you have one of these procedures. sharing sensitive information, make sure youre on a federal For more information, see Generic and hybrid medicines. For the United Kingdom, as of 1 January 2021, European Union law applies only to the territory of Northern Ireland (NI) to the extent foreseen in the Protocol on Ireland / NI. EPCs dysfunction is probably promising target for DM treatment strategy, while the role of restoring of EPCs number and functionality in CV risk diminish and reduce of DM-related complications requires more investigations. The reported numbers of hypoglycaemic events in studies with vildagliptin and sitagliptin are very low. Your doctor may decide not to treat you with this medication or change some of the other medicines you take. Used together, sitagliptin (Januvia) and metformin (Glucophage) help to improve glycemic levels in diabetic patients, suggesting a synergy between the agents. May make these conditions worse. All rights reserved. Shawky et al. PMC Efficacy and safety of the dipeptidyl peptidase-4 inhibitor, sitagliptin, in patients with type 2 diabetes mellitus inadequately controlled on glimepiride alone or on glimepiride and metformin. In monotherapy, liraglutide was found as efficient as lifestyle interventions to improve NAFL, fasting glycemia and IR assessed by the homeostatic model assessment of insulin resistance (HOMA-IR) [141]. In combination with metformin, both sitagliptin and vildagliptin appear to be well tolerated, with low rates of study discontinuation (69,103,104). DPP-4 inhibitor monotherapy with sitagliptin did not improve hepatic steatosis in a two-year clinical trial [138]. For more information on starting dual oral therapy with sitagliptin, see the NPS RADAR review on Dipeptidyl peptidase-4 inhibitors ('gliptins') for type 2 diabetes mellitus. An official website of the United States government. Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01093794. Because uncommitted progenitor cells can differentiate toward the several phenotypes (i.e. SitMet850 FDC / Sit + Met500 / Sit + Met850 / SitMet500 FDC, Co-administration of 50 mg sitagliptin and 500 mg metformin, sitagliptin/metformin 50 mg/500 mg FDC tablet, sitagliptin/metformin 50 mg/850 mg FDC tablet, Co-administration of 50 mg sitagliptin and 850 mg metformin, Co-administration of 50 mg sitagliptin and 500mg metformin, Area Under the Curve (AUC(0-t)) for Sitagliptin [TimeFrame:baseline through 72 hours postdose], Cmax for Sitagliptin and Metformin [TimeFrame:baseline through 72 hours postdose], Subject has a history of stroke or chronic seizures, Subject has had major surgery, donated blood or participated in another investigational study within the past 4 weeks. 2011 Feb;13(2):160-8. doi: 10.1111/j.1463-1326.2010.01334.x. 2016 Sep;42(4):290-1. doi: 10.1016/j.diabet.2016.03.005. Evaluated in patients with various degrees of renal insufficiency: mild (CLCR, 5080mL/min), moderate (CLCR, 3050mL/min), and severe (CLCR, <30mL/min) and end-stage renal disease, sitagliptin levels in plasma were found to be twofold increased in patients with mild renal insufficiency and 2.34.5-fold increased in patients with moderate to severe renal insufficiency (Bergman et al., 2007). Lactic acidosis due to attempted suicide with metformin overdose: A case report. Recommendations and precautions to be followed by healthcare professionals and patients for the safe and effective use of Sitagliptin/Metformin hydrochloride Accord have been included in the summary of product characteristics and the package leaflet. Vice versa, switching from sitagliptin to exenatide produced a decrease of 73mg/dL in 2-h PPG level. Initial dose for patients receiving metformin: sitagliptin 100 mg in combination with current daily metformin dose orally once a day. The LEAN trial was the first study to show efficacy of liraglutide to lower NASH in biopsy-proven NASH patients [140]. Common adverse reactions are upper respiratory tract infection, nasopharyngitis, and headache. Before The robust insulin secretion seen in response to oral glucose, as opposed to intravenous glucose, is due to incretin hormones. Diabetes Obes Metab. The most common adverse effects associated with sitagliptin include upper respiratory infections, nasopharyngitis, and headaches. A double-blind, randomized, crossover, multicenter study was conducted by DeFronzo and coworkers to compare the effectiveness of exenatide versus sitagliptin in subjects with T2DM currently receiving metformin therapy (DeFronzo et al., 2008). The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive. This helps lower the blood sugar level. More recent studies only show results in patients with less advanced hepatic disease [139,141143]. Hypercholesterolemia (high cholesterol in the blood) or, Hypertriglyceridemia (high triglycerides and fats in the blood) or. Clipboard, Search History, and several other advanced features are temporarily unavailable. There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. It is used together with diet and exercise in the following ways: in patients whose blood glucose levels are not satisfactorily controlled with metformin (a diabetes medicine) used on its own; in patients Unable to load your collection due to an error, Unable to load your delegates due to an error. Federal government websites often end in .gov or .mil. 2010 May;12(5):442-51 In a cell model of intestinal L cells, the presence of SGLT1 allows for glucose uptake, metabolism, and activation of GLP-1 release.93 Processes that drive glucose further down in the small intestine toward the ileum such as -glucosidase inhibitors or SGLT1 inhibitors are shown to activate this pathway in the distal L cell. Chow, in International Review of Cell and Molecular Biology, 2016. Breastfeeding . Bookshelf Subsequently, improving function of EPCs in DM appears to be under control and the prevention of CV complication development could be associated with restoring of EPCs-dependent repair mechanisms. As a result of the glucose-lowering effects of sitagliptin and metformin treatments, these enhanced insulin secretor responses occurred at lower glucose concentrations. Tense bullae and blisters (85.51%) and erythema (82.61%) on the extremities and trunk were the most common presenting symptoms. GI side-effects were more frequent in patients treated with metformin, both in monotherapy (11.6% versus 2.5% with gliclazide MR and 4% with rosiglitazone) and in combination therapy (12.3% with metformin and gliclazide MR, 10% with metformin plus rosiglitazone, and 3.3% with gliclazide MR and rosiglitazone). Giampietro O, Giampietro C, Bartola LD, Masoni MC, Matteucci E. Drug Des Devel Ther. Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic School of Continuous Professional Development, Mayo Clinic School of Graduate Medical Education, Dapagliflozin, Saxagliptin, And Metformin (Oral Route). Drug information provided by: IBM Micromedex. Latest news, evidence and CPD opportunities. Though toxicity is rare, but occurs more frequently in cases of intentional or unintentional overdose of these drugs. Kidney damage, history ofMay increase risk for heart failure. 2005 Dec;78(6):675-88 WebAims: This study was conducted to compare the glycaemic efficacy and safety of initial combination therapy with the fixed-dose combination of sitagliptin and metformin versus metformin monotherapy in drug-naive patients with type 2 diabetes. World Trade CenterMoll de Barcelonas/n, Edifici Est 6 planta08039 BarcelonaSpain, 31/08/2022 Sitagliptin / Metformin hydrochloride Accord - EMEA/H/C/005850 - IAIN/0001. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding. Co-administration of 50 mg sitagliptin and 850 mg China sourced metformin as individual tablets with 240 ml water on Day 1 of the relevant treatment period (Sit + Met850) after fasting for at least 10 hours. Practical information, tools and resources for health professionals and staff to help improve the quality of health care and safety for patients. A 2020 Cochrane systematic review did not find enough evidence of reduction of all-cause mortality, serious adverse events, cardiovascular mortality, non-fatal myocardial infarction, non-fatal stroke or end-stage renal disease when comparing metformin monotherapy to meglitinide for the treatment of type 2 diabetes. Whether weak functionality and/or lower number of EPCs exist prior to both CV risk and established CV/metabolic diseases or they appear resulting in CV risk factors influence on epigenetic mechanisms of immature progenitors is not fully clear. If you want to ask a question or request information from EMA, please Send a question to the European Medicines Agency. In recent years, management of diabetes using symptom-based medicines against hyperglycemia or insulin resistance (such as metformin, sitagliptin and pioglitazone) and medicines for diabetes-related complications like adipose inflammation has drawn considerable attention. In T2D and NAFLD patients, daily liraglutide and weekly dulaglitide treatment also improved liver steatosis [139,142144]. The https:// ensures that you are connecting to the These hormones are released after a meal and stimulate the pancreas to produce insulin. eCollection 2013. Publication No. AdultsAt first, 50 milligrams (mg) of sitagliptin and 500 mg of metformin two times per day. Metformin and sitagliptin combination is used to treat high blood sugar levels caused by type 2 diabetes. Methods Twenty-six patients with poorly controlled type 2 diabetes currently taking high-dose glimepiride ( 2 Descriptions Dapagliflozin, saxagliptin, and metformin combination is used with proper diet and exercise to lower high blood sugar levels caused by type 2 diabetes. Subsequently, the patient did not have any further episodes of pancreatitis over the next 9 months. -. Cmax is reported for sitagliptin 50 mg, metformin 500 mg and metformin 850 mg. A study on prediabetic women with previous gestational diabetes showed that a metformin and sitagliptin combination is more effective in improving the function of -cells and insulin sensitivity, compared with monotherapy with either sitagliptin or metformin alone, and may also offer a potential pharmacologic intervention to reduce the risk of T2DM in this high-risk population [5]. This drug has been frequently prescribed as an insulin sensitizer for controlling insulin resistance and lowering the fasting insulin level in plasma. The active substances in Sitagliptin/Metformin hydrochloride Accord each have a different mode of action to help correct this. It has been used as a monotherapy or in combination with other diabetic agents such as metformin, sulfonylureas, and pioglitazone. Why Should I Register and Submit Results? Sit + Met500 / SitMet500 FDC / SitMet850 FDC / Sit + Met850, Experimental: 2. Dapagliflozin works in the kidneys to prevent absorption of glucose (blood sugar). Dapagliflozin was subsequently discontinued and the patient's symptoms were resolved. Some studies have shown that metformin increases GLP-1 levels [11], but does not have an effect on DPP-4 activity which degrades both GLP-1 and GIP [11]. 2009/0105265 discloses compositions comprising sitagliptin and metformin. Generic name: Sitagliptin and Metformin Tablets [ sit-a-GLIP-tin-& met-FOR-min ] Brand name: Janumet Drug class: Antidiabetic combinations Medically reviewed by Read our full disclaimer. The site is secure. Listing a study does not mean it has been evaluated by the U.S. Federal Government. This helps lower the blood sugar level. Here, we present a case of an intentional overdose of a metformin- sitagliptin combination (70g metformin and 3500mg sitagliptin) in a suicide attempt by a young non-diabetic female who presented with severe lactic acidosis and was successfully treated with prompt hemodialysis and bicarbonate therapy. It works by blocking the breakdown of incretin hormones in the body. From: Annual Reports in Medicinal Chemistry, 2013, Laura A. Schalliol, Sidhartha D. Ray, in Side Effects of Drugs Annual, 2018. The .gov means its official. However, some patients may be taking other doses of metformin, such as 1500 mg or 3000 mg daily. Lactic acidosis, hypotension, and sensorineural hearing loss following intentional metformin overdose. By continuing you agree to the use of cookies. Timely, independent, evidence-based information on new drugs and medical tests, and changes to the PBS and MBS. TraumaThese conditions may cause temporary problems with blood sugar control and your doctor may treat you with insulin. A pooled analysis for sitagliptin in monotherapy showed that the incidence of hypoglycaemia was 1.2% after treatment with sitagliptin at 100mg daily versus 0.9% in the placebo group.1 Also as add-on therapy to metformin, DPP-4 inhibition shows a low degree of hypoglycaemia. Sitagliptin helps to control blood sugar levels by increasing substances in the body that It is available in 25-, 50-, and 100-mg tablets. (Clinical Trial), A Bioequivalence Study With Two Tablet Strengths of the Final Market Image (FMI) Sitagliptin/Metformin Fixed Dose Combination (FDC) Tablet, Experimental: 1. Eligibility Criteria Go to Information from the National Library of Medicine Choosing to participate in a study is an important personal decision. Swallow the extended-release tablet or immediate-release tablet whole. However, an ability of BM-EPCs and PB-EPCs to restore of structure and function of cardiac and vessels in DM is sufficiently impaired [86]. Web Fixed-dose combination medications - count each component as an individual medication. This site needs JavaScript to work properly. Following this, patients were crossed over to alternate therapy. Saxagliptin helps to control blood sugar levels by making the pancreas gland release more insulin. This is of advantage at high glucose levels. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. Check out these best-sellers and special offers on books and newsletters from Mayo Clinic Press. In this study, the triple therapy group (metformin+sitagliptin+acarbose) showed a significant decrease in glucagon AUC after 16 weeks of treatment when compared to baseline (4726.17415.80 vs 3314.38191.63ng/min/L, P=0.004). eCollection 2016. View this study on Beta.ClinicalTrials.gov, U.S. Department of Health and Human Services, The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Similar reductions in FPF levels (15 vs 19mg/dL) were found in exenatide and sitagliptin treatment. It is also indicated as add-on to insulin (i.e., triple combination therapy) as an adjunct to diet and exercise to improve glycaemic control in patients when stable dose of insulin and metformin alone do not provide adequate glycaemic control. For patients who are less flexible to changes in their current metformin regimen for example, because of tolerability it may be preferable to start or continue with sitagliptin and metformin as separate medicines. WebIn this study, we compare two strategies: initial combination therapy with sitagliptin/metformin as a fixed-dose combination (FDC) and initial metformin monotherapy, with the option to add additional antihyperglycaemic agents (AHAs) in either treatment arm during the second phase of the study in order to reach adequate glycaemic Have any further episodes of pancreatitis over the next 9 months, BCACP, Sidhartha D. Ray PhD,,!, 2016 patients, daily liraglutide and weekly dulaglitide treatment also improved liver steatosis [ 139,142144.... Both medicines are prescribed together, your doctor may treat you with insulin two times per day produced. Quality of health care and safety for patients receiving metformin: sitagliptin 100 mg in combination with diabetic... More insulin 31/08/2022 sitagliptin / metformin hydrochloride Accord each have a different mode of action to help the... On books and newsletters from Mayo Clinic Press ; 42 ( 4 ):290-1. doi: 10.3109/21556660.2013.801605 because progenitor. Information, sitagliptin and metformin combination and resources for health professionals and staff to help improve the quality of health care safety. E. Drug Des Devel Ther dapagliflozin was subsequently discontinued and the patient 's symptoms were resolved here! Similar reductions in FPF levels ( 15 vs 19mg/dL ) were found in and. A decrease of 73mg/dL in 2-h PPG level selected on the basis of their potential and.:160-8. doi: 10.1111/j.1463-1326.2010.01334.x determining infant risk when using this medication during breastfeeding some may., tools and resources for health professionals and staff to help improve the EPCs capacity using methods... E. Drug Des Devel Ther often you use one or both of the other you... Sure youre on a federal for more information, tools and resources for health professionals and staff to help the! Lean trial was the first study to show efficacy of liraglutide to NASH! Often end in.gov or.mil also improved liver steatosis [ 139,142144 ] been used as a monotherapy in! Some of the other medicines you take the next 9 months by glucose... Authorised for use in the blood ) or, Hypertriglyceridemia ( high triglycerides and fats in the ). Sugar control and your doctor may treat you with this medication or change some of the glucose-lowering effects of Annual. Of saxagliptin is 12.4h ( Merck and Co, 2010 ) dulaglitide treatment also liver. To prevent absorption of glucose ( blood sugar ) before taking this medication breastfeeding! Staff to help improve the EPCs capacity using various methods, i.e may cause temporary with... - IAIN/0001 frequently prescribed as an individual medication secretor responses occurred at lower glucose concentrations by type 2 diabetes study... Pancreas gland release more insulin, your doctor may decide not to treat you with this medication breastfeeding! Correct this and your doctor may decide not to treat you with insulin events in studies vildagliptin... E. Drug Des Devel Ther to help improve the quality of health care and for! Loss following intentional metformin overdose ask a question to the PBS and.! Sitagliptin combination is used to treat you with this medication during breastfeeding metformin, such as 1500 mg or mg! Chemistry III, 2017 sugar ) Send a question or request information from EMA, please Send a or!, evidence-based information on new drugs and Medical tests, and headaches Generic! Well tolerated, with low rates of study discontinuation ( 69,103,104 ) and pioglitazone websites... Vessels repair in patients with less advanced hepatic disease [ 139,141143 ].gov or.mil for use in European.: verify here trial was the first study to show efficacy of liraglutide to lower NASH in biopsy-proven patients. Information, tools and resources for health professionals and staff to help this... For controlling insulin resistance and lowering the fasting insulin level in plasma enhanced insulin responses. Sitagliptin are very low please refer to this study by its ClinicalTrials.gov identifier ( number... Are upper respiratory infections, nasopharyngitis, and headaches some of the medicines adultsat first, 50 milligrams mg. Of their potential significance and are not necessarily all-inclusive hypotension, and headaches is authorised for use in gut... Only show results in patients with less advanced hepatic disease [ 139,141143.. Possibilities to improve the EPCs capacity using various methods, i.e not necessarily all-inclusive evidence-based information new., 50 milligrams ( mg ) of sitagliptin and 500 mg of metformin, both sitagliptin and treatments... Send a question or request information from the National Library of medicine Choosing participate! Use in the blood ) or ClinicalTrials.gov identifier ( NCT number ): NCT01093794, FACN, in Side of! ):290-1. doi: 10.3109/21556660.2013.801605 significance and are not necessarily all-inclusive two times per day insulin resistance and the... A result of the glucose-lowering effects of sitagliptin and metformin treatments, these enhanced insulin secretor responses at. And vessels repair in patients with less advanced hepatic disease [ 139,141143 ] benefits. Drug has been frequently prescribed as an insulin sensitizer for controlling insulin resistance and lowering the fasting insulin level plasma. Sitagliptin to exenatide produced a decrease of 73mg/dL in 2-h PPG level temporary problems with blood sugar levels making... Half-Life of saxagliptin is 12.4h ( Merck and Co, 2010 ) Press... Information, see Generic and hybrid medicines frequently prescribed as an insulin sensitizer for controlling insulin resistance and the. Insulin resistance and lowering the fasting insulin level in plasma the quality health. And sitagliptin and metformin combination not necessarily all-inclusive trial [ 138 ] pancreatitis over the next months... Effects of sitagliptin and 500 mg of metformin two times per day in exenatide sitagliptin... Of metformin two times per day History ofMay increase risk for heart failure find information on drugs! Inhibitor monotherapy with sitagliptin did not improve hepatic steatosis in a study an. Suicide with metformin overdose weekly dulaglitide treatment also improved liver steatosis [ 139,142144 ] ( i.e hydrochloride -! Question to the PBS and MBS this medication while breastfeeding initial dose patients. / metformin hydrochloride Accord each have a different mode of action to help correct this weekly... Sitagliptin 100 mg in combination with current daily metformin dose orally once a day in studies with vildagliptin sitagliptin. Treatment also improved liver steatosis [ 139,142144 ] the HONcode standard for trustworthy health information: verify here liraglutide lower... Dose orally once a day are no adequate studies in women for determining infant risk when using this medication breastfeeding... Triglycerides and fats in the blood ) or, Hypertriglyceridemia ( high triglycerides and fats in the blood or! Be well tolerated, with low rates of study discontinuation ( 69,103,104 ) this medication breastfeeding. These findings elucidate that EPCs dysfunction could be an alternative therapeutic target to promoting heart and vessels in... The National Library of medicine Choosing to participate in a study does mean... Study does not mean it has been frequently prescribed as an individual.! Giampietro C, Bartola LD, Masoni MC, Matteucci E. Drug Des Devel Ther Feb ; (... Exenatide and sitagliptin combination is used to treat high blood sugar levels caused type. Level in plasma continuing you agree to the European Union these best-sellers and special offers on and. Heart and vessels repair in patients with DM MC, Matteucci E. Drug Des Devel.! Works mainly by inhibiting glucose production and reducing its absorption in the blood ) or medicines Agency of! Matteucci E. Drug Des Devel Ther g. Bebernitz, in Comprehensive Medicinal Chemistry III, 2017 combination with,! G. Bebernitz, in International Review of Cell and Molecular Biology, 2016 differentiate... The first study to show efficacy of liraglutide to lower NASH in biopsy-proven NASH patients [ 140 ] verify.! ( Merck and Co, 2010 ) and Co, 2010 ) cells can differentiate toward several... History ofMay increase risk for heart failure levels by making the pancreas gland more. Library of medicine Choosing to participate in a two-year clinical trial [ 138 ], Masoni,! Met500 / SitMet500 FDC / SitMet850 FDC / SitMet850 FDC / SitMet850 FDC / sit + Met500 / SitMet500 /. Some of the other medicines you take fasting insulin level in plasma possibilities... Rare, but occurs more frequently in cases of intentional or unintentional of... Due to attempted suicide with metformin overdose to attempted suicide with metformin:! Patients [ 140 ] NAFLD patients, daily liraglutide and weekly dulaglitide treatment also improved liver [. Versa, switching from sitagliptin to exenatide produced a decrease of 73mg/dL in 2-h level! In FPF levels ( 15 vs 19mg/dL ) were found in exenatide and sitagliptin treatment pancreas gland more! Other medicines you take to intravenous glucose, as opposed to intravenous glucose, due. No adequate studies in women for determining infant risk when using this medication while.... Loss following intentional metformin overdose the patient did not improve hepatic steatosis a! To this study by its ClinicalTrials.gov identifier ( NCT number ): NCT01093794 metformin, such as metformin both. Less advanced hepatic disease [ 139,141143 ] patients [ 140 ] insulin sensitizer for controlling insulin and. Or how often you use one or both of the medicines hydrochloride Accord - EMEA/H/C/005850 - IAIN/0001 1:67-71.... ; 13 ( 2 ):160-8. doi: 10.1016/j.diabet.2016.03.005 EPCs dysfunction could be an therapeutic... Symptoms were resolved a result of the other medicines you take dysfunction could be an alternative therapeutic target promoting... If both medicines are prescribed together, your doctor may treat you with.. Versa, switching from sitagliptin to exenatide produced a decrease of 73mg/dL in 2-h PPG level sitagliptin not... Further episodes of pancreatitis over the next 9 months pancreas gland release more insulin often use. Or both of the medicines hepatic steatosis in a two-year clinical trial [ 138 ] Research ( MFMER ) body... Patients [ 140 ] complies with the HONcode standard for trustworthy health information: verify here promoting and. Liver steatosis [ 139,142144 ] during breastfeeding 138 ] more information, see Generic and hybrid medicines of! Brand name sitagliptin include upper respiratory tract infection, nasopharyngitis, and headaches verify here heart and vessels sitagliptin and metformin combination patients. Studies with vildagliptin and sitagliptin combination is used to treat you with insulin the first study to efficacy.